The flavonoid derivatives such as engeletin, isorhamnetin, and quercetin are the main constituents for the treatment of PID by inhibiting extracellular regulatory protein kinase and SMAD2/3 protein phosphorylation, thereby relieving the degree of fibrosis in the uterus via ERK1/2 and TGFβ-SMAD2/3 signaling pathways [17]. The gene discussed is SMAD2; the disease is pelvic inflammatory disease.