AKT3 and Hirschsprung disease: Peng et al. (2017) found that circ-ZNF609 participates in the pathogenesis of congenital megacolon via the mir-150-5P/AKT3 pathway. Zhou et al. performed a sequencing analysis of human congenital megacolon specimens and found that the down-regulation of circ-PRKCI could inhibit cell proliferation and differentiation and inhibit the expression of the mir-1324 target gene PLCB1 (Zhou et al., 2018).