For instance, in cervical cancer (Li et al., 2019), NUSAP1 is shown to bound to the SUMO-E3 ligase Ran binding protein 2 (RanBP2) to induce the sumoylation of TCF4, thereby enhancing the Wnt/β signaling pathway and inducing tumor metastasis. This evidence concerns the gene NUSAP1 and cervical carcinoma.