Bystander activation leads to host injury mediated by exerting a higher level cytotoxicity that is further facilitated by natural killer cell-activating receptors, such as NKG2D, and cytolytic molecules, such as granzyme B. Therefore, hypothetically a small number of activated CD8+ T cells infiltrating into a “cold” tumor may exert both T cell receptor dependent and independent cytotoxic effects on the cancer cells. Here, CD8A is linked to neoplasm.