EGF and neoplasm: A well-described, reciprocal paracrine loop between the two cell types, involving colony stimulating factor-1 (CSF1) secretion from the tumor cell and epidermal growth factor (EGF) secretion from the macrophage, leads to the chemotactic attraction of one cell towards the other, coupling them in sequence in a unique migratory pattern called “cancer cell streaming” (104, 119, 120).