Indeed, the conditional ablation of the VEGFA gene via targeted expression of Cre recombinase under the control of the macrophage-specific promoter that regulates transcription of the colony stimulated factor-1 receptor (CSF1R) in a mouse model of breast carcinoma results in successful assembly of TMEM-doorways, which are otherwise entirely incapable of breaking down endothelial junctions and facilitating cancer cell transendothelial migration and intravasation (128). This evidence concerns the gene VEGFA and cancer.