HGF and neoplasm: Cancer cells that overexpress MENAINV are characterized by formation of extracellular matrix-degrading cellular protrusions, called invadopodia, by increased sensitivity to chemotactic factors in the tumor microenvironment such as epidermal growth factor (EGF) and hepatocyte growth factor (HGF), which both facilitate cancer cell invasion and migration (75, 98, 107–114).