Others, like ANG2, are also critical for cancer cell dissemination, as ANG2-dependent activation of TIE2 receptor in the TMEM macrophage leads to the localized production and secretion of VEGF, which in turn, is critical for TMEM-associated vascular opening and the transendothelial migration of MENAINV+ tumor cells (75, 98). The gene discussed is ANGPT2; the disease is neoplasm.