ANGPT2 and cancer: Under the transcriptional control of the Ang2-Tie2 signaling axis, TIE2+ TMEM macrophages can locally release large quantities of proangiogenic factors, most prominently VEGFA, which is critical for both eliciting an angiogenesis program and sustaining TMEM function and TMEM-mediated cancer cell dissemination (128, 188–190).