WNK2 and neoplasm: Besides DDR pathway, we selected six pathways, homologous recombination repair (HRR), Janus kinase (JAK), mitogen-activated protein kinase (MAPK), phosphoinositide 3-kinase (PI3K), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), Wnt, through literature survey, which are associated with tumor immunity or immunotherapy escape (41, 42).