HIF1A and cancer: HIF-1α expression promotes cancer glycolysis and evasion of immunosurveillance, at the same time, tampering with anti-tumor immunity directly by inhibiting NKG2D expression in NK cells (26, 27), reducing CD4+ effector T cell differentiation (28), promoting regulatory T cell differentiation and activity, elevating checkpoint molecule expression (29, 30), as well as inducing T cell apoptosis (31).