Of all tumors, 30 (22%) were hormonally active (insulinomas n=18 [60%], gastrinomas n=4 [13%], somatostatinomas n=2 [7%], VIPoma n=1 [3%], glucagonoma n=1 [3%], PTHrp related hypercalcemia n=1 [3%] and lesions secreting multiple hormones n=3 [10%, gastrin + glucagon n=1, and insulin + glucagon n=2]). This evidence concerns the gene PTHLH and pancreatic insulinoma.