The main goals of the authors (in the case of T2D) were to identify DEGs in skeletal muscle in insulin resistance, a major risk factor for T2D (non-insulin-dependent) diabetes, and to compare the gene expression patterns of skeletal muscle tissues from 18 insulin-sensitive versus 17 insulin-resistant, equally obese, and non-diabetic Pima Indians for which global transcript profiling has been performed (36). Here, INS is linked to type 1 diabetes mellitus.