Cell adhesion molecules, PI3K—AKT, and MAPK pathways appear highly enriched in both conditions; there is regulation of the actin cytoskeleton, cAMP, and phospholipase D; Focal adhesion is exclusively and highly enriched in the case of T2D; and hematopoietic cell lineage and phagosomes are potentially enriched in cases of obesity. Here, AKT1 is linked to obesity due to melanocortin 4 receptor deficiency.