Notably elevated apolipoprotein-B (Apo-B) (the major component of low/very low density lipoprotein cholesterol, LDL/VLDL) in clinically isolated syndrome (before confirmed MS diagnosis) correlated positively with increased Expanded Disability Status Scale (EDSS) indicating that cholesterol levels could serve as biomarkers for disease progression (74, 75), even accounting for age as a confounder. The gene discussed is APOB; the disease is Down syndrome.