Moreover, compared to patients with non-PolyVD and IL-6 < 2.64 pg/ml, those with non-PolyVD with IL-6 ≥ 2.64 pg/ml (HR: 1.245, 95% CI 1.072–1.446; P = 0.004) and PolyVD with IL-6 < 2.64 pg/ml (HR: 1.251, 95% CI: 1.002–1.563; P = 0.04) were associated with an increased risk of recurrent stroke within 1 year after adjusting for the confounding factors. Here, IL6 is linked to stroke disorder.