In this study, it is observed that patients with PolyVD or patients with elevated IL-6 levels were all associated with increased risk of recurrent stroke compared with patients with non-PolyVD and IL-6 <2.64 pg/ml, however, AIS/TIA patients with both PolyVD and elevated IL-6 levels had the highest risk of recurrent stroke among groups, indicating that PolyVD and plaque instability had a combined effect on adverse outcomes. The gene discussed is IL6; the disease is Stroke.