After adjusting for age, gender, education, current smoking, heavy drinking, medical history of hypertension, DM, dyslipidemia, IS, AF, infection, NIHSS at admission, the subtype of stroke, medication and DBP (mmHg), BMI (mean±SD), glucose (mmol/L), TC (mmol/L), TG (mmol/L), LDL (mmol/L), and HDL (mmol/L), patients with PolyVD and IL-6 ≥ 2.64 pg/mL had an increased risk of recurrent stroke at 1-year follow-up compared to those with non-PolyVD and IL-6 < 2.64 pg/ml, the adjusted HR (95% CI) was 1.290 (1.058–1.572); P = 0.01. The gene discussed is IL6; the disease is infection.