According to the result of current research, less expression of the main factor of mitochondrial biogenesis, Pgc-1α, may be related to the volume of tumor development, thus suggesting that is being a mechanistic basis to diminish tumor volume growth following the decline of expression of Pgc-1αmRNA in combination of IET and vitamin D. So, the findings of this study are consistent with previous research that demonstrates the delay of possible tumor development and smaller-sized tumors (Malicka et al., 2015; Alvarado et al., 2016; Faustino-Rocha et al., 2016, 2017; Sturgeon et al., 2017). Here, PPARGC1A is linked to neoplasm.