A recent report highlighted the potential therapeutic targets in modulating microglial functions for Alzheimer’s disease (AD) as NLRP3 inflammasome activation (VRAC, P2X7, NLRP3), complement production and signalling (C1, C1q, C3, CR1, Factor B, Factor D, and Properdin), and TREM2/DAP12 signalling (TREM2, SHIP-1, PLCγ2, and Apolipoprotein E) (Nizami et al., 2019). Here, INPP5D is linked to Alzheimer disease.