The tau protein hyper-phosphorylation observed at Ser202/Thr205, Thr212, Ser214, Thr217, Ser262, and Ser422 amino acid residues in AD due to oxidative stress results in neurofibrillary tangles via self-assembly of paired helical filaments admixed with straight filaments (Miao et al., 2019). Here, MAPT is linked to Alzheimer disease.