Candesartan cilexetil, is a synthetic, benzimidazole-derived angiotensin II receptor antagonist prodrug with antihypertensive activity also observed to inhibit TLR2 and TLR4 expression in PD which in turn may reverse microglial phenotype from pro-inflammatory to anti-inflammatory in the oligomeric α-synuclein microenvironment (Daniele et al., 2015; Liu et al., 2019). Here, SNCA is linked to Parkinson disease.