ICAM1 and ischemia: ICAM-1, as a cell-surface glycoprotein member of the immunoglobulin superfamily, participates in the trafficking and adhesion of leukocytes to activated ischemia endothelia in stroke, so ICAM-1-induced intervention has become a promising therapeutic strategy against stroke (Choi et al., 2011; Mizuma and Yenari, 2017).