Particularly, older degus have been shown to develop molecular hallmarks of AD such as an increase in Aβ peptides and phosphorylated Tau expression (Inestrosa et al., 2005, 2015; Van Groen et al., 2011; Ardiles et al., 2012, 2013; Tarragon et al., 2013; Du et al., 2015; Szabadfi et al., 2015; Cisternas et al., 2018). Here, MAPT is linked to Alzheimer disease.