SLC1A2 and early-onset autosomal dominant Alzheimer disease: Significant lower levels of EAAT2 have also been reported in vitro (Scimemi et al., 2013) and in vivo, in animal models of Alzheimer’s disease (Wilson et al., 2003; Dabir et al., 2006; Mookherjee et al., 2011; Schallier et al., 2011; Hefendehl et al., 2016), as well as in humans affected by this disease (Li et al., 1997; Jacob et al., 2007; Scott et al., 2011; Leng et al., 2021), whereas promoting EAAT2 expression improves cognitive function (Fan et al., 2018).