Fluorescence Recovery After Photobleaching (FRAP) experiments in neuroblastoma 2a cells show that 50% of membrane GAT1 is immobile, likely due to the existence of tight interactions between GAT1 and the actin cytoskeleton, mediated by the adaptor protein ezrin (Imoukhuede et al., 2009). The gene discussed is SLC6A1; the disease is neuroblastoma.