NOGO proteins have been implicated in glioma cell invasion,58 tumour angiogenesis59 and regulation of blood vessel homeostasis.60,61 In contrast, gap junction protein 2B (GJB2, also known as Connexin26) is a structural component of gap junctions62–67 and is expressed at the plasma membranes of cells. The gene discussed is GJB2; the disease is central nervous system cancer.