To analyse the relationship between segmentation results and patient survival, we next performed Pearson correlation analysis between the area of different brain tumour regions and patient survival across (i) all TCGA glioblastomas, and (ii) brain tumours harbouring the 13 most frequent mutations (PTEN, TP53, EGFR, NF1, PIK3CA, PI3KR1, TRAPP, ATRX, PDGFRA, KMT2C, PB1, GRIN2A, IDH1; see Supplementary Fig. 3 for tumour region size distribution across different patient’s cohorts). The gene discussed is KMT2C; the disease is glioblastoma.