RTN4 and breast carcinoma: GJB2 has previously been identified as a gene associated with prognostic value in brain68,69 and pancreatic cancers70,71 and contribute to tumorigenesis in breast cancer.72 Survival plots of TCGA GBM data for patients with low and high expression of GJB2 and RTN4 reveal their association with a poor prognosis in glioblastoma (Fig. 5c).