RTN4R and Familial prostate cancer: However, more recent data in prostate cancer has shown that RTN4 regulates cell fate and its overexpression led to cell cycle arrest and senescence.90 Besides, RTN4 binding to RTN4R, the more established receptor RTN4, contributes to ROCK and STAT3 activation in the cell expressing RTN4R,88 which can contribute to glioblastoma tumour cells invasion (through ROCK91) and chronic microglia activation (through ROCK and STAT392,93).