Interestingly, we also note that in patients harbouring mutations in the NF1, PTEN, TRAPP, TP53 and PIK3CA, there is a strong positive correlation between survival and central tumour regions (i.e. CT and CTpnz) but little or no correlation with the other infiltrative regions LE, IT and CTmvp). The gene discussed is PIK3CA; the disease is neoplasm.