Cancer cells are constantly exposed to replication stress and replication-associated DDR, which may in turn activate MRE11 expression [10, 38], but we found no association between MRE11 expression and the expression of phosphorylated ATM, phosphorylated ATR, and γ-H2AX in oral cancer tissues (Fig. S9). The gene discussed is MRE11; the disease is lip and oral cavity carcinoma.