TGFBR2 and adenomyosis: We found that mRNA levels of Kcnk2 were decreased in the uteri of Tgfbr2 cKO at PD10 (Fig. 4n), indicating the altered ion channels and myometrial function upon conditional deletion of Tgfbr2. As disruption of stromal-myometrial interaction occurs in adenomyosis, a pathological condition characterized by the presence of uterine glands/stroma inside the smooth muscle compartment23, we speculated that the disorganized myometrium might impact endometrial differentiation.