PCa cases with the major allele G in rs4783709 and the minor allele G in rs17632542 in KLK3 had a higher risk of PCa aggressiveness (P = 4.6 × 10–16; OR= 1.29 per one unit of the G × G allele with a coding of 0, 1, 2 for each allele) in the combined set. Here, KLK3 is linked to posterior cortical atrophy.