Though the prevalence of aggressive PCa for the entire cohort was 23% (Fig. 3A), the prevalence among the cases with the AA + AA genotype in rs3775202 + rs174776 in VEGFC and KLK3 was 54% (OR= 4.12 for AA + AA genotype compared with others; P = 5.9 × 10–7) in the combined set. Here, KLK3 is linked to posterior cortical atrophy.