MAPK1 and posterior cortical atrophy: For the most significant SNP pair of rs2266967 (MAPK1) + rs7446 (KPNA3), PCa cases with the CA/AA + AG/AA genotype had a higher risk of PCa aggressiveness (OR= 1.21; P = 3.6 × 10–8) compared to cases with other genotypes for this SNP pair.