These overlapping genes were enriched for the 'TNFR2 non-canonical NFκB pathway’ in Reactome and included immune genes such as CD200, MAP4K3 & PDCD1, IL21 (a key regulator in CeD) and IL22 (a regulator of intestinal epithelial homeostasis45) (Suppl. Here, NFKB1 is linked to cranioectodermal dysplasia.