IL12B and psoriasis: Among them, the drug indications of 63 targeted proteins matched the corresponding GWAS traits, indicating that the pathogenic genes excavated by GWASs had a higher probability of being directly used as drug targets.105 For example, the IL12B (interleukin 12B) gene found in psoriasis GWASs encodes the target of ustekinumab, a newly proven drug for psoriasis.