BCMA has gained the ‘holy grail’ recognition for the CAR T-cell field in myeloma and as long as continuous effort is invested into circumventing the barriers that have limited the success of current BCMA-directed CAR T-cell products, we may soon be able to produce an optimized product for MM that could be within the same realm of success as CD19-targeting CARs in lymphomas and ALL. The gene discussed is CD19; the disease is Miyoshi myopathy.