CGAS and age-related macular degeneration: In addition, several studies have revealed that cGAS activation by self-DNA derived from chromatin instability (CIN), damaged mitochondria, micronuclei, or cell debris was connected to more familial and complex diseases, including myocardial infarction (MI) and age-related macular degeneration (AMD).57 MI has a high fatality rate in human, concomitant with increased inflammation and immune responses.