Hypoxia-responsive miRNAs including miR-93 and miR-25 were reported to remarkably downregulate cGAS expression in the immunosuppressive tumor microenvironment (TME) through targeting NCOA3 for suppression.70 Thus elevated expression of miR-93/25 observed in breast cancer facilitates tumor evasion from immune surveillance and destruction partially through downregulating cGAS expression. This evidence concerns the gene CGAS and breast carcinoma.