CGAS and cancer: Interestingly, some copper (Cu2+) complexes used in anticancer therapy inhibit topoisomerase 1 and 2, leading to DNA breaks and DNA fragments to activate cGAS signaling.167 Notably, transporters for these ions have been observed dysregulated in cancer,168 and it is plausible altered ion transport in cancer may facilitate cancer evasion of immune surveillance by modulating cGAS signaling.