CGAS and infection: Interestingly, hcGAS-Lys198 acetylation was found to be decreased by quantitative proteomics upon infection by either HSV-1 or HCMV (human cytomegalovirus), suggesting that these DNA viruses might hijack this acetylation regulation to targetedly inactivate cGAS to evade innate-immune surveillance.127 The detailed mechanism(s) mediating acetylation-dependent cGAS activity control on these sites remain unclear.