To determine the effect of miR-126-3p on Erk1/2, PI3K/Akt, and p38 MAPK signaling, western blotting was performed 2 h after IL-1β-induced OA-CH were transfected with hsa-miR-126-3p-mimic-NC, hsa-miR-126-3p-mimic, hsa-miR-126-3p-inhibitor-NC, and hsa-miR-126-3p-inhibitor. The gene discussed is AKT1; the disease is cyclic hematopoiesis.