On the one hand, activated SIK2 can activate the PI3K-AKT signalling pathway to promote cancer cell proliferation and survival; on the other hand, it can inhibit acetyl-coenzyme A carboxylase in combination with AMPK phosphorylation, increasing the expression of carnitine palmitoyl transferase 1 and activating FAO, thereby promoting omental metastasis of ovarian cancer [112]. Here, AKT1 is linked to cancer.