However, compared with that of bone and lung metastasis, the expression of HIF-1α and HIF-1α target PDK1 expression are at a higher level in liver cancer metastasis, resulting in stronger downstream glycolytic activity; however, oxidation phosphorylation and glutamine metabolism are weaker in the liver, which promotes the adaptation of cancer cells to the hypoxic environment in the liver [73]. This evidence concerns the gene HIF1A and cancer.