Two meta-analyses reviewed five HSP70 polymorphisms (rs1043618, rs1061581, rs2075800, rs2227956, and rs2763979) and found that the rs1061581 and rs2227956 polymorphisms were significantly associated with NIHL in Caucasian males, but no significant association of any of the five SNPs with NIHL was found in Asian populations [13, 14]. Here, HSPA1A is linked to noise induced hearing loss.