MBD2 and neoplasm: Studies in mice also support the importance of epigenome regulation in MB: targeting chromatin remodeling with a combination of DNA methyltransferases (DNMT) inhibitor 5-aza-2′deoxycytidine (5-aza-dC) and histone deacetylases (HDAC) inhibitor valproic acid (VPA) effectively inhibits tumor formation in the patched homolog (Ptch) heterozygous mice, a model of SHH-MB [6], and antagonizing methyl-CpG binding protein methyl-CpG binding domain protein 2 (MBD2) inhibits MB xenografts [7].