To determine the carcinogenic effect of miR-503-5p/CXCL10-mediated HDAC2 in ESCC, KYSE30 and Ec109 cells with HDAC2 low expression were further transfected with miR-503-5p inhibitor or pcDNA-CXCL10. The gene discussed is HDAC2; the disease is esophageal squamous cell carcinoma.