It was outlined that miR-503-5p inhibitor or pcDNA-CXCL10 increased CXCL10 expression (Fig. 7a) and miR-503-5p inhibitor or pcDNA-CXCL10 functionally reversed the effects of HDAC2 knockout on ESCC cells (Fig. 7b–g). This evidence concerns the gene HDAC2 and esophageal squamous cell carcinoma.