HDAC2 and esophageal squamous cell carcinoma: Conducted by a prior study, it is stressed out that HDAC2 expression is elevated in ESCC tissues, connecting with lymph node metastasis, invasion depth, histological grade, TNM stage and knocking down HDAC2 obstructs ESCC cells to proliferate, arrests G0/G1 phase cell cycle and accelerates apoptosis [7].