GSTM1 and Increased total leukocyte count: Since chronic inflammation usually leads to leukocytosis, anemia, thrombocytosis, and elevated ESR, CRP, C3, and C4 [24], laboratory tests including WBC, Hb, PLT, ESR, CRP, C3, and C4 are routinely performed at our clinics to provide another objective parameters for JIA evaluation.