In another example, the RA lead SNP overlaps with an H3K27ac peak located near the promoter of ETV7 which showed higher activity in both RA SF CD4+ T cells compared to the respective cell types from RA PBMC (FDR: 1.6×10−3) and healthy PBMC (FDR: 5.7×10−5). This evidence concerns the gene CD4 and rheumatoid arthritis.