CD4 and rheumatoid arthritis: We found that while the estimated RA heritability was similarly enriched in ATAC-seq peaks from unstimulated immune cells and in H3K27ac peaks from RA PBMC and Healthy PMBC (∼20-fold), the heritability enrichment was greater in H3K27ac peaks from RA SF B cells, CD4+ T cells, and Tregs than in ATAC-seq peaks from in vitro stimulation of the same cell types (Fig. 6f).