APOE and hyperlipoproteinemia type 3: In addition, therapeutics that modulate APOE function to make it more “APOE-ε3-like” or “ε2-like” have been explored with relatively positive results in vitro and in murine models [79], though there are important considerations with regard to lipid health as homozygous ε2 carriers are likely to have a higher incidence of type III hyperlipoproteinemia [81].