Moreover, BACE2 hyperactivates NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) pathway, through a series of phosphorylation cascade of different member of this pathway, such as p65, IKKβ (inhibitor of nuclear factor kappa-B kinase subunit beta) and IKBα (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), increasing tumor growth [46]. Here, IKBKB is linked to neoplasm.