Indeed, by interrogating GTEx (Genotype-Tissue Expression) and TCGA (The Cancer Genome Atlas) mRNA expression datasets through GEPIA (Gene Expression Profiling Interactive Analysis) [47], it is evident that BACE2 is upregulated in a broad range of tumors (Fig. 3) while BACE1 does not appear to be dysregulated in cancer. This evidence concerns the gene BACE2 and cancer.