For instance, the significant up-regulation of miR-107 expression can be observed in gastric cancer (GC) tissues and cell lines, and miR-107 promotes GC cell proliferation and represses the apoptosis through the targeted regulation of PTEN [15]; conversely, miR-107 expression is markedly reduced in OC cell lines and tissues, and through the targeted inhibition of CCNE1, miR-107 induces the G0/G1 arrest of OC cells, and significantly inhibits their colony-forming ability [17]. This evidence concerns the gene PTEN and gastric cancer.