IRF1 and neoplasm: Wei [39] demonstrated the correlations of the high CXCL13 expression with lower OS and larger tumor diameter in GC.Yuan [40] supported the role of IRF-1 in hindering GC metastasis, which was achieved through the reduction of Wnt/β-catenin signaling and the downregulation of MIR17HG-miR-18a/miR-19a axis expression.