BCL2 and acute myeloid leukemia: Moreover, we found downregulation of CPT1a sentitized BCL-2 inhibitor ABT199 and CPT1a-selective inhibitor ST1326 combined with ABT199 had a strong synergistic effect to induce apoptosis in AML cells and primary patient blasts for the first time, providing a proper scheme for the problem of ABT199 resistence in AML.