HOXC8 and neoplasm: The up-regulated genes included: (1) genes involving in tumorigenesis promoters (such as RASGRP3, ErbB3, HOXC8; (2) genes correlating with energy metabolism (such as FFAR3,ND3); (3) Leucocyte Receptor Complex:LAIR2,LILRB1,LILRA4.The down-regulated genes included: (1) immune system activators such as ICAM1,CD40; (2) Hematopoietic tumor suppressor such as KLF5, ALOX5.