Transcriptome studies showed that impaired METTL3 methylation results in the generation of PTCs in the mRNAs of several SRSFs, contrary to the existing scenario in malignant gliomas, which are associated with elevated expression of METTL3 and lower expression levels of SRSFs NMD spliced forms [183]. The gene discussed is METTL3; the disease is malignant glioma.