RB1 and Familial gastric cancer: Indeed, several tumor suppressor genes were found to present PTC-introducing mutations in a plethora of cancers, like p53 in mantle-cell lymphoma [23] and breast cancers [20], E-cadherin (CDH1) gene in hereditary diffuse gastric cancers (HDGC) [155], retinoblastoma 1 (RB1) gene in mantle-cell lymphoma [23], breast cancer type 1 susceptibility protein (BRCA1) gene in breast and ovarian cancers [22], and breast cancer type 2 susceptibility protein (BRCA2) gene in breast cancers [25].