Reportedly, HMGB1 can promote the invasion of NSCLC cells by activating PI3K/Akt and NF-κB pathways to produce MMP-9[24]; in metastatic pancreatic ductal adenocarcinoma, HMGB1 promotes EMT and invasion of cancer cells by acting on RAGE/NF-κB axis. The gene discussed is AKT1; the disease is cancer.