Indeed, molecular modeling and mutation assays revealed the interaction between β-carotene and the NLRP3 PYD; the oral administration of β-carotene in mice was proven to reduce the inflammation and to diminish IL-1β secretion from human synovial fluid cells isolated from gouty patients, demonstrating its inhibitory efficacy in human gout [82]. The gene discussed is NLRP3; the disease is gout.