Many loci associated with gout are known to code for proteins directly involved in processing NLRP3 inflammasome, including membrane bound receptors, transcriptional regulators, ion channels, lipoproteins, and the inflammasome molecules (i.e., APOA1, APOC3, CARD8, CD14, NLRP3, PPARGC1B, P2RX7, and TLR4). Here, TLR4 is linked to gout.