RHO and retinal detachment: The evidence supporting the second hypothesis includes: (1) the dramatic accumulation of all-trans-retinyl ester (precursor of rhodopsin) in RPE, (2) disorganized and unhealthy rod OS that aggravates the resistive barrier [46,84,85,86] and (3) altered RPE/photoreceptor interface due to subretinal administration induced retinal detachment [87].