PPARG and obesity due to melanocortin 4 receptor deficiency: Interestingly, RXR and PPARγ antagonism was reported to ameliorate high-fat diet (HFD)-induced obesity and IR through reduction of triacylglycerol (TAG) in WAT, skeletal muscle, and liver in KKAy mice (a genetic model for obesity-diabetes syndrome) in contrast with untreated mice [24].