When deemed necessary to improve thrombocytopenia, such as in high bleeding risk surgery, treatment can involve platelet transfusion or, in some cases, TPO-RA (eltrombopag, romiplostin) [1,7,164,165,166,167,170,172,173] (reviewed in Bastida el al in this special issue). This evidence concerns the gene TPO and Thrombocytopenia.