Recently, Eisfeld et al. [45] reported reduced survival for patients in the ELN2017 favorable-risk group who harbored mutations in BCOR or SETBP1. Our findings underline the complexity of the mutational landscape of AML, where even mutational variants of rare mutations have to be considered in order to determine their clinical and prognostic effects. Here, SETBP1 is linked to acute myeloid leukemia.