Four target genes were associated with the highest number of transcription factors (n = 10), and interestingly all of these four genes have previously been implicated in PCa: BUD31 encodes for a bona-fide AR-coactivator that enhances AR transactivation in prostate cells [31]; PLOD3 is involved in tissue remodelling and plays a role in multiple tumour types including PCa [32]; SDR42E1 is implicated in early prostate organogenesis as well as carcinogenesis [33] and XAGE1A belongs to the cancer testis antigens family and its expression profile is linked to the aggressiveness of PCa [34]. Here, PLOD3 is linked to posterior cortical atrophy.