DNMT1 and cancer: Consistently, among the ten most frequently active transcription factors (regulators) in these two datasets, we found three known genes implicated in PCa progression: BACH1 promotes invasion and migration of PCa cells by altering metastasis related genes [39]; CITED2 (Cbp/P300 Interacting Transactivator With Glu/Asp Rich Carboxy-Terminal Domain 2) has recently been proposed as a therapeutic target to tackle PCa metastasis [40]; and DNMT1 promotes PCa metastasis through the regulation of epithelial-mesenchymal transition and cancer stem cells [41].