PRL and Graves disease: Seven women in the folic acid group had a clinical history of medical disease (one patient with diabetes, one with chronic respiratory disease, one with epilepsy, one with hypothyroidism, one with diabetes, one had allergies, and another a psychiatric disorder) as compared to five women in the placebo group (three had endocrinologic disorders—hypothyroidism, autoimmune hyperthyroidism and prolactin-producing pituitary adenoma—and two had a coagulation disorder).