In females, Danon disease should be considered if they present with either dilated or hypertrophic cardiomyopathy, retinal changes, mildly increased (or normal) creatine kinase (CK), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) with preserved hepatic synthetic function [127]. This evidence concerns the gene GPT and hypertrophic cardiomyopathy.