Nevertheless, the interest in FTO protein has led to the discovery of its engagement in a wide range of key physiological processes such as adipogenesis [6], osteogenesis [7], neural development [8], heart remodeling [9] and cell cycle progression [10], as summarized in Figure 1A. Moreover, FTO dysfunctions lead to major disturbances like cancer [11,12,13,14,15,16] and improper brain development [17]. The gene discussed is FTO; the disease is cancer.