Expression analysis of cancer drug resistance genes further confirmed the involvement of cell cycle regulators in miR-217-induced sensitivity to gemcitabine exposition, especially in PANC-1 cells, in which CCND1, CCNE1, CDK2, CDKN1A, and CDKN1B, all participating in the transit across S phase, resulted in down-regulation. Here, CDKN1B is linked to cancer.