In addition, the higher Insulin-like growth factor 2 mRNA-binding protein 2 was found in head and neck squamous cell carcinoma and correlated with higher cancer stage and larger tumor size [17], while the presence of ADAMTS14 SNP rs12774070 was significantly associated with the degree of oral tumor cell differentiation [37]. The gene discussed is ADAMTS14; the disease is head and neck squamous cell carcinoma.