In the subgroup analysis that only enrolled the oral cancer patients without alcohol drinking, the GAS5 SNP rs145204276 variants (Ins/Del or Del/Del) in this population were associated with significantly advanced tumor stage (OR: 1.500, 95% CI: 1.081–2.081, p = 0.015) and larger tumor size (OR: 1.494, 95% CI: 1.076–2.074, p = 0.016). The gene discussed is GAS5; the disease is lip and oral cavity carcinoma.