Many cachexia-inducing factors such as activin A (ActA) [17], myostatin (Mstn) [18], and growth/differentiation factor 15 (GDF15) [19] are members of the transforming growth factor (TGF)-β family, capable of inducing muscle wasting and fat loss in preclinical cancer cachexia models. The gene discussed is MSTN; the disease is Cachexia.