In a comprehensive study that tested levels of 25 circulating factors such as TNF-α, IFN-γ, IL-1β, and IL-6 in cachectic and weight stable patients, monocyte chemoattractant protein-1 (MCP-1) was the only biomarker significantly increased in cachectic patients with pancreatic cancer [11]. The gene discussed is CCL2; the disease is familial pancreatic carcinoma.